Thesis (Ph.D.), University of Manchester, School of Biological Sciences.
|Contributions||University of Manchester. School of Biological Sciences.|
|The Physical Object|
|Number of Pages||357|
The Human Type VI Collagen Gene. mRNA and Protein Variants of the Alpha 3 Chain Generated by Alternative Splicing of an Additional 5-end Exon J Biol Chem. Nov 25;(33)Cited by: Multiple Forms of Chicken a3(VI) Collagen Chain Generated by Alternative Splicing in Type A Repeated Domains Roberto Doliana, Paolo Bonaldo, and Alfonso Colombatti Divisione di Oncologia Sperimentale 2 Centro Di Riferimento Oncologico, Aviano, Italy Abstract. Type VI collagen . Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice Ari Hiltunen a'*, Marjo Mets/iranta b, Merja Per/il/i b, Anna-Marja . FEBS FEBS Letters () 17l Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice Ari .
Alternative splicing of VWFA modules generates variants of type VI collagen α3 chain with a distinctive expression pattern in embryonic chicken tissues and potentially different adhesive function. Conversely, alternative splicing of the human α2 (VI) transcript was found to generate three different protein variants, referred to as α2C2, α2C2a and α2C2a′ (Saitta et al., ) (see poster). In . Type VI collagen (COL6) forms a microfibrillar network associated with type I collagen fibrils. The expression of COL6 has been linked to inflammation and survival. Importantly, tumor-specific . Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function and stabilizes the cell membrane. It is .
Splicing of four vWF type A domains from the N-terminus of the α3(VI) chain would generate a protein of approximately kDa, which is within the range of α3(VI) chain variants seen after electrophoresis of tissue and cell culture-derived collagen VI . Keywords: type II procollagen, precursor mRNA, alternative splicing, chondrocyte differentiation, cartilage, type XI collagen, extracellular matrix Introduction The removal of introns (i.e. splicing) . Complex alternative splicing patt~erns of the a2(VI) and a3(VI) chains have been described at the mRNA level. The C2 domain of the a2(VI) collagen chain undergoes alternative splicing to produce . Alternative splicing of transcripts for the alpha 3 chain of mouse collagen VI: identification of an abundant isoform lacking domains N7-N10 in mouse and human. Dziadek M(1), Kazenwadel JS, .